The most versatile barrier membrane for periodontal applications

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The most versatile barrier membrane for periodontal applications


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A patient sustained a fall, causing a maxillary fracture and loss of teeth. (Photos: Snoasis Medical)

Fri. 5 November 2021


While placental tissues have been used in medical procedures for more than 100 years,[1,2] Snoasis Medical pioneered their use in dentoalveolar applications in 2007.

Snoasis Medical’s placental tissue membrane, BioXclude, is a versatile, deepithelialized amnion-chorion membrane that provides full barrier function with inherent bioactive growth factors and signaling molecules to promote healing.[3]

Placental-derived tissues are immunoprivileged,4 alleviating concerns for rejection or adverse reaction. Additionally, amnion-chorion allograft membranes have been shown to have potent antimicrobial properties,[5,6] making them ideally suited for surgical procedures in oral and maxillofacial environments. Together, these properties make BioXclude the superior barrier membrane option, according to the company.

Robert J. Miller, DMD, has fully adopted BioXclude as the best and most versatile patient option for his private practices in Florida.

Miller said: “Predictability and ease of use have made BioXclude my go-to membrane for over eight years.”

In the presented case from Miller, the patient sustained a fall, causing a maxillary fracture and loss of teeth #7, 8 and 9.

An allograft ring was used to place an implant at site #9, along with xenograft bone and a collagen membrane. An implant was also placed at site #7, using FDBA and BioXclude to regenerate the buccal plate.

As you can see from the final CT scans, both sides were equally successful.

This case only represents the tip of the iceberg. Numerous studies have demonstrated the efficacy of BioXclude across periodontal regenerative procedures. Snoasis Medical asserts that it sets the standard for placental membrane research in dentistry with more than 10 years of research and 46 clinical publications to date, making BioXclude the most researched placental membrane in dentistry.


  1. Davis JW 1910, Skin transplantation with a review of 550 cases at the Johns Hopkins Hospital. Johns Hopkins Med J15:307.
  2. Stern W 1913, The  grafting of preserved amniotic membrane to burned and ulcerated skin surfaces substituting skin grafts. JAMA 13:973–974.
  3. Wallace S, Cobb C. 2011, JIACD 3(6); 61-72.
  4. Insauti CL, et al. Amniotic membrane-derived stem cells: immunomodulatory properties and potential clinical application. Stem Cells and Cloning: Advances and Applications. 2014:7;53-63.
  5. Ashraf H, Font K, Powell C, Schurr M. Antimicrobial Activity of an Amnion-Chorion Membrane to Oral Microbes. Int  J  Dent. 2019 Jul 11;2019:1269534.
  6. Palanker N, Lee C, Tribble G, et al. Antimicrobial efficacy assessment of human derived amnion-chorion. University  of  Texas  at  Houston  Health  Sciences  Center  Graduate  Periodontics  (Houston,  TX).  Poster presentation  #27 at American Academy of  Periodontology Meeting 2018, Vancouver, BC.

(Source: Snoasis Medical)

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