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While placental tissues have been used in medical procedures for more than 100 years,[1,2] Snoasis Medical established their use in dentoalveolar applications in 2007. Snoasis Medical’s placental tissue membrane, BioXclude, is a versatile, deepithelialized amnion-chorion membrane that provides full barrier function with inherent bioactive growth factors and signaling molecules to promote healing.
Placental-derived tissues are immunoprivileged, alleviating concerns for rejection or adverse reaction. Additionally, amnion-chorion allograft membranes have been shown to have potent antimicrobial properties,[5,6] making them ideally suited for surgical procedures in oral and maxillofacial environments. Together, these properties make BioXclude the superior barrier membrane option.
Anthony Del Vecchio, DDS, a diplomate of the American Board of Oral and Maxillofacial Surgeons, has fully adopted BioXclude as the best and most versatile patient option for his private practices in New York.
Three of Del Vecchio’s BioXclude cases are described.
In Case 1, BioXclude is left exposed as a barrier in a typical atraumatic extraction with site preservation. BioXclude is only required to be tucked under the gingival margin, eliminating the need for flap elevation. It may safely touch tooth and root surfaces, implant surfaces and exposed nerves, making trimming unnecessary. Accelerated post-operative healing is observed at only four days, with decreased pain and swelling at the extraction site.[7,8]
In Case 2, BioXclude is used for an all-on-four procedure with zygomatic implant placement via lateral window approach in a former smoker with a severely atrophic maxilla. The membrane adapts ideally over large lateral access window as an adhesion barrier and replacement for buccal fat advancement. In this case, the ability of BioXclude to adhere to surrounding structures without requiring additional stabilization highlights the superior handling properties.
In Case 3, BioXclude is used in the reconstruction of an atrophic mandible in a former cancer patient. Mental nerve lateralization using BioXclude as a nerve wrap (a technique developed in orthopedic and urologic procedures)[9,10] resulted in a successful reconstruction without additional ridge augmentation with all-on-four placement. Upon post-operative evaluation, the patient had minimal edema and no paresthesia symptoms were reported.
These cases represent only the tip of the iceberg. Numerous studies have demonstrated the benefits of using amniotic tissue for neural regeneration,11 bisphosphonate-induced osteonecrosis of the jaw,12 and a plethora of orthopedic and chronic wound indications.
Snoasis Medical can be found online at www.snoasismedical.com and can be contacted directly at (866) 521-8247.
A full list of references is available from the publisher.
(Source: Snoasis Medical)