Columbia University announces break-through in tooth regeneration

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Columbia University announces break-through in tooth regeneration

Human molar scaffold. (DTI/Photo courtesy by Columbia University, USA)
Daniel Zimmermann, DTI

Daniel Zimmermann, DTI

Wed. 26 May 2010


NEW YORK, USA/LEIPZIG, Germany: Dental implants could soon become a secondary choice for replacing natural teeth. According to new research from the College of Dental Medicine at Columbia University in New York, three-dimensional scaffolds infused with stem cells could yield an anatomically correct tooth in as soon as nine weeks once implanted. The new technique, developed by Columbia University professor Jeremy Mao, has also shown potential to regenerate periodontal ligaments and alveolar bone, which could make way to re-grow natural teeth that fully integrate into the surrounding tissue.

Previous research on tooth regeneration has been focusing on harvesting stem cells directly on dental implants to improve osseointegration or outside the body where the tooth is grown under laboratory conditions and implanted once it has matured. Mao’s technique, which has been tested on animal-models, is moving the harvesting process directly into the socket where the tooth can be grown ‘orthotopically’.

“A key consideration in tooth regeneration is finding a cost-effective approach that can translate into therapies for patients who cannot afford or who aren’t good candidates for dental implants,” Dr Mao told Dental Tribune Asia Pacific. “Our findings represent the first report of regeneration of anatomically shaped tooth-like structures in vivo.”

Dr Mao’s study has been published in the recent Journal of Dental Research and will be presented at this year’s International Association of Dental Research congress in Barcelona. Columbia has also announced to have filed patient applications in relation to the engineered tooth and is actively seeking partners to help commercialise the technology through its technology transfer office Columbia Technology Ventures.

21 thoughts on “Columbia University announces break-through in tooth regeneration

  1. Joy Distad says:

    This could potentially save lives, including mine. This is hope to us, that suffer with teeth loss and or pain issues by oral health. Teeth are critical for nourishment. Teeth effect total body including mental health. This is amazing news to me. I pray I will live, here on earth, to see this as an opportunity for myself.
    I would appreciate being in any trial for this or being a patient to receive stem cell regeneration of teeth.

  2. harleydave says:

    how would this process work on a patient with a loss of bone mass?? i have bone mass loss to the point that i am unable to get traditional implants. is there any hope for me to take part in this dream?? thanks

  3. Lula Holmes says:

    I would like to be part of the clinical trials

  4. Robert Baker says:

    When & where can I get it done ✅

  5. Crystal says:

    Where do I sign up …my location ( Spain )

  6. Isabelle says:

    Does this also work for only tooth enamel?

  7. Sandra Ore says:


    Is there an update on the commercialization of this procedure – the regrowth of teeth through stem cells at Columbia University College of Dental Medicine? Have family that are interested and would benefit from it. Please do respond.

  8. Lana McLean says:

    I live in Australia and I would like to register as a volunteer for any human trials in Australia (Melbourne)

  9. Chad Zelasney says:

    I’m very interested in this as I’m not a good candidate for regular dentistry.

  10. Evens says:

    Where can I get this done please.

  11. Hannah says:

    Where and how do I sign up ?

  12. Syed Farhan says:

    If you need a volunteer for regrowing teeth i’m interested to co-operat.

  13. Kamila says:

    Chcę zapytać czy mogę odnowić zęby. Proszę o kontakt. Pozdrawiam

  14. Carolyn says:

    I would love to get my teeth regrown. My son has two that need to be regrown

  15. Carolyn Ricker says:

    Where can we get this done? My son has two teeth that need to be regrown.

  16. Where can I get this done , l live in New York City and I would love to volunteer in regrowing your own teeth and bone. When can I get more information about this breakthrough.
    Thank you
    Juanita mejia

  17. Wendy Sawyer says:

    Where can I get this done? Also I would be interested in being a volunteer on the missing replacing teeth. I have had several stem cells procedures with 100% success. I live in Southern California

  18. Marilyn Bloch says:

    I would be interested in being a volunteer in this program to test regeneration of teeth

  19. maxine simons says:

    where can I get this done as a volunteer testing in Dallas, Tx.

  20. Shaterra wells says:

    Where can i get this done

  21. susie says:

    If you need volunteers to test this break through then I am your gal!

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