Dental News - Ancient teeth bacteria track disease evolution

Dental Tribune USA

Wed. 8 May 2013

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NEW YORK, N.Y., USA: DNA preserved in calcified bacteria on the teeth of ancient human skeletons has shed light on the health consequences of the evolving diet and behavior from the Stone Age to the modern day. The ancient genetic record reveals the negative changes in oral bacteria brought about by the dietary shifts as humans became farmers, and later with the introduction of food manufacturing in the Industrial Revolution.

An international team, led by the University of Adelaide's Centre for Ancient DNA (ACAD) in Australia, where the research was performed, published the results in Nature Genetics in February. Other team members include the Department of Archaeology at the University of Aberdeen and the Wellcome Trust Sanger Institute in Cambridge, United Kingdom.

“This is the first record of how our evolution over the last 7,500 years has impacted the bacteria we carry with us, and the important health consequences,” said study leader professor Alan Cooper, ACAD director. “Oral bacteria in modern man are markedly less diverse than historic populations, and this is thought to contribute to chronic oral and other disease in post-industrial lifestyles.”

The researchers extracted DNA from tartar (calcified dental plaque) from 34 prehistoric northern European human skeletons and traced changes in the nature of oral bacteria from the last hunter-gatherers, through the first farmers to the Bronze Age and Medieval times.

Dental plaque represents the only easily accessible source of preserved human bacteria,” said lead author Dr. Christina Adler, who conducted the research as a PhD student at the University of Adelaide and is now at the University of Sydney. “Genetic analysis of plaque can create a powerful new record of dietary impacts, health changes and oral pathogen genomic evolution, deep into the past,” she said.

Cooper said, “The composition of oral bacteria changed markedly with the introduction of farming, and again around 150 years ago. With the introduction of processed sugar and flour in the Industrial Revolution, we can see a dramatically decreased diversity in our oral bacteria, allowing domination by caries-causing strains. The modern mouth basically exists in a permanent disease state.”

Cooper has been working on the project for the past 17 years with archaeologist and co-leader Keith Dobney, a professor at the University of Aberdeen. Dobney said, "I had shown tartar deposits commonly found on ancient teeth were dense masses of solid calcified bacteria and food, but couldn't identify the species of bacteria. Ancient DNA was the obvious answer."

The team was not able to sufficiently control background levels of bacterial contamination until 2007, when ACAD’s ultra-clean laboratories and strict decontamination and authentication protocols became available.

Researchers worked with a team of dentists at the University of Adelaide’s School of Dentistry to establish a picture of microbial diversity in modern-day mouths and the relationship between bacteria in plaque and calculus.

Adler wrote, “One common cause of gum disease, porphyromonas gingivalis, had been suggested to lie behind recent rises in heart disease. However, we were able to show it had not increased in prevalence over the past 7,000 years, suggesting it was not likely to be causative. However, it may contribute to the disease by stimulating a permanent state of inflammation.”

The research team is now expanding its studies through time, and around the world, including other species such as Neanderthals.

(Source: The University of Adelaide)

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