Dental News - Oral therapy for multiple sclerosis patients gets approval

AFP

Tue. 26 January 2010

save

WASHINGTON, DC, USA: A newly-tested treatment for multiple sclerosis reduces relapse and deterioration in patients, without many of the negative side effects associated with other treatments. A clinical study published Wednesday in the New England Journal of Medicine (NEJM) said that Cladribine, which is produced by pharmaceutical group Merck Serono, was the first oral medication for patients suffering from multiple sclerosis, a complex neurological condition.

A team led by Gavin Giovanonni, a professor at Barts and The London School of Medicine and Dentistry in Britain, followed some 1,300 patients for nearly two years, monitoring them with MRI scans.Patients were either given two or four short courses of Cladribine tablets over the course of a year or were administered a placebo. The results were heartening, with those taking the Cladribine tablets over 55 percent less likely to suffer relapse and 30 percent less likely to suffer worsening in their disability due to multiple sclerosis.

The disease is a neurological condition that often begins in young adulthood and involves the body's immune system attacking its own central nervous system. The damage done interferes with communications between the brain and other parts of the body leading to disability.

Patients are often required to undergo regular injections and intravenous infusions, but Cladribine, which works by suppressing the immune system, only needs to be taken for between eight to 10 days a year to work effectively, the study found.

"The introduction of an oral therapy, particularly one that has no short-term side effects and is as easy to use as oral Cladribine, will have a major impact on the treatment of multiple sclerosis," Giovanonni said:

Merck Serono's request to put the drug on the market was rejected by the US Food and Drug Administration at the beginning of December. It is now in discussions with the US regulatory body and seeking to resubmit its application, according to a statement from the company.

Multiple sclerosis usually affects people between 20 and 40 years old, and its symptoms can be serious and crippling. It can affect almost all of the biological functions that control movement, sensory perception and memory.

An estimated one in 1,000 people are affected by the disease.

To post a reply please login or register

Examining patient financing: Good for your patients. Good for your practice.

We hear about it a lot these days — dental practices getting squeezed by lower consumer spending. The result is less treatment acceptance and lower ...

Chicago Dental Society Midwinter Meeting: vVARDIS showcases oral care solutions for orthodontic patients

CHICAGO, US: Additional oral hygiene measures are usually recommended to supplement daily toothbrushing in orthodontic patients because they are prone to ...

Versatilt lets wheelchair patients recline in comfort

Vancouver/New York, USA: Dentists might find it awkward to treat patients who are in wheelchairs. For those who can’t be transferred into a dental ...

‘WarLess’ procedure allows heart patients to continue anticoagulation therapy

NEW YORK, N.Y., USA: Dental implant surgery procedures can conflict with the medication needs of heart patients. A less invasive approach to dental implants...

Vibraject: The multiple-use dental needle accessory for endodontic procedures

The VibraJect multiple-use Dental Needle Accessory is unique in that it can be effectively utilized for endodontic irrigation by merely attaching it to the ...

Recommending the right powered brush for orthodontic patients

During orthodontic therapy, only excellent oral hygiene leads to excellent results. However, dental professionals are not always sure of recommendations to ...

Oral surgery protocol to control bleeding for heart patients shows positive results

NEW YORK, N.Y., USA: Cardiac patients who take anticoagulant medications and need a tooth extraction face an increased risk of bleeding that must be ...

New study could help reduce pain in oral cancer patients

NEW YORK, US: Oral tumours can cause agonising pain and thus greatly impair the quality of life of patients. Researchers from the New York University ...

At last: A fully robotic toothbrush for disabled patients

KRIENS, Switzerland: According to World Health Organization data, almost 45% of the global population has some form of oral disease. For people with a ...

Trackside partnership produces multiple winners

LOUISVILLE, Ky., USA: During a check-up at the Kentucky Racing Health Services Center (KRHSC), one patient is diagnosed with an abscessed tooth and another ...

Education

Live webinar
Mon. 29 April 2024
12:30 PM EST (New York)