Dental News - Novalar launches dental anaesthesia reversal agent

Daniel Zimmermann, DTI

Sun. 1 March 2009

save

LEIPZIG, Germany: The US pharmaceutical company Novalar has launched their latest premier dental product OraVerse at the Chicago Midwinter Meeting held in Chicago in February. The product is the first local anaesthesia reversal agent that accelerates the return to normal sensation and function for patients who wish to avoid the lingering soft tissue anaesthesia following routine dental procedures in which a local anaesthetic containing a vasoconstrictor was used.

OraVerse was approved by the US Food and Drug Administration last year as safe and effective for adults and children six years and older and weighing 33 lbs. In two randomised, double-blinded, controlled Phase 3 studies, the agent reduced the median time to recovery of normal sensation in the lower and upper lip to approximately half the time compared to the control. Both studies were conducted on over 400 patients in 18 centres across the US.

“How to address soft tissue numbness is one of the most commonly asked questions in dentistry,” Dr Stanley Malamed, Professor of Anaesthesia & Medicine at the University of Southern California School of Dentistry, said. “OraVerse is the first solution of its kind that dentists can use to finally answer this question. It will provide dentists with a convenient alternative for completing routine dental procedures that allows patients to comfortably return to their daily routine”.

The active ingredient in OraVerse is phentolamine mesylate, a drug already used in other medical applications, such as the prevention or control of hypertensive episodes that may occur in patients with pheochromocytoma because of stress or manipulation during preoperative preparation and surgical excision. According to the company, OraVerse will come in a standard dental cartridge that can be easily injected utilising the same injection site and an identical technique to that of a local anaesthetic. It is used in a 1:1 ratio to local anaesthetic and has been tested in doses of 0.5, 1 and 2 cartridges.

To post a reply please login or register

Antibacterial agent boosts toothpaste effectiveness

NEW YORK, N.Y., USA: Regular use of fluoride toothpaste containing triclosan, an antibacterial agent, and a copolymer, which helps prevent the triclosan ...

Novalar enters licence agreement for launching OraVerse in Germany

NEW YORK, USA/LEIPZIG, Germany: Novalar Pharmaceuticals has announced to have chosen Sanofi-Aventis Deutschland as exclusive distributor of their OraVerse ...

Milestone hands distribution of dental anesthesia system to Aseptico

LIVINGSTON, N.J., & WOODINVILLE, Wash., USA: Aseptico has been announced as new distributor for Milestone Scientific's Single Tooth Anesthesia (STA) in ...

Curve Dental launches Curve GRO

PROVO, Utah, USA: Curve Dental, a provider of cloud-based dental solutions, has announced the release of Curve GRO, the company’s next-generation patient ...

Making general anesthesia an affordable option for pediatric dental care

NEW YORK, N.Y., USA: In some situations, general anesthesia is the best option for pediatric dental patients undergoing treatment. However, the cost of such...

Weave launches payment platform for dental practices

NEW YORK, U.S.: Weave, a Utah-based startup company and one of the fastest-growing companies in technology, has taken the opportunity at the 2019 Greater ...

Fotona launches ST PRO Lightwalker dental laser

DALLAS, Texas, USA: Fotona, based in the U.S. and Europe, will launch its new ST PRO Lightwalker dental laser at the upcoming 151st Midwinter Meeting of the...

Finnigan Enterprises launches Oxford Scientific Dental Products

Finnigan Enterprises announced the launch of Oxford Scientific Dental Products at the American Dental Association’s annual meeting, held recently in ...

Remington College-Tampa launches dental assistant program

TAMPA, FL, USA: Those who are interested in joining the growing dental field now have an additional educational option. Remington College–Tampa Campus...

The fight for anaesthesia safety in dentistry—Part 2

Carrying on the conversation from the first part on the ongoing fight for improved safety in anaesthesia in dentistry, Dental Tribune International again ...

Education

Live webinar
Thu. 11 September 2025
1:00 PM EST (New York)