Dental News - Pulpdent awarded two patents for stabilized calcium phosphate molecule

Dental Tribune USA

Mon. 10 January 2022

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WATERTOWN, Mass., USA: Pulpdent has been awarded two patents by the United States Patent and Trademark Office for a stabilized calcium phosphate molecule. When placed in a dental composite, the bioactive molecule facilitates tooth remineralization, promotes hydroxyapatite formation and performs at the highest levels of esthetic dentistry, the company said.

The discovery has the potential to impact millions of patients worldwide by significantly improving the outcomes of dental restorative procedures, according to Pulpdent.

The patented molecule, a methacrylate-functionalized calcium phosphate (MCP), exists in a highly active, transitional state at the molecular level. When placed in a dental restorative material in the oral environment, MCP is capable of transferring calcium, phosphate and fluoride from saliva to tooth structure and creating a scaffold for mineral precipitation, apatite formation and biomineralization, Pulpdent said. Unlike any bioactive material introduced to date, it also allows for uncompromised, esthetic anterior restorations, the company said.

“The advent of Pulpdent’s two MCP patents represents the culmination of decades of research by our science team,” said Pulpdent Vice President Don Berk. “The behavior of the MCP molecule was discovered in an effort to push dentistry to a new era of restorative possibilities — one characterized by materials that actively promote tooth health while also meeting the esthetic demands of smile-zone dentistry. By introducing MCP to the marketplace and to dental professionals across the world, we’ve taken an incredible leap to fulfill our mission of fundamentally improving dental care.”

Pulpdent’s MCP molecule will be marketed under the trade name Crysta. It will be immediately available in many of Pulpdent’s restorative products, including ACTIVA Presto, ACTIVA Pronto and Lime-Lite Enhanced.

“Our research and development team has already begun studying the use of Crysta MCP technology in our extensive product portfolio,” said Pulpdent President Fred Berk. “We expect Crysta to quickly become a cornerstone of Pulpdent’s market success and a key differentiator in establishing standards for restorative treatment. We are at the beginning of the Crysta MCP story, and the next 10 years will see this technology shape dental practices and touch the lives of millions of dental patients in a very real way. We see the MCP patents as a once-in-a-generation development that can enhance the practice of dentistry and the longevity of tooth-color composite restorations.”

Currently, ACTIVA Presto and ACTIVA Pronto, the recently introduced, first-ever universal light-cure esthetic bioactive composites, and Lime-Lite Enhanced, Pulpdent’s market-leading cavity liner, contain MCP. The company plans to introduce MCP to additional materials, including both new and legacy Pulpdent products.

MCP’s remineralization properties resemble those that occur in natural dental tissues. Dental restorative materials containing MCP stimulate hydroxyapatite formation and become “sealed” to healthy tooth structure, according to Pulpdent. As a result, restorations with MCP act as a deterrent against secondary caries, a well-known cause of dental restoration failure, the company said.

Both in-vivo and in-vitro research by Pulpdent demonstrated MCP’s novel ability to create nucleation sites for hydroxyapatite formation, the company said. Hydroxyapatite precipitation on the surfaces of composites was evaluated using attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS).

Pulpdent’s original research, which includes the achievement of MCP-containing materials that produce optimal esthetics (tooth shade matching) and flexural strength, was recently published in the peer-reviewed journal Polymers. The article, titled “Experimental Dental Composites Containing a Novel Methacrylate-Functionalized Calcium Phosphate Component: Evaluation of Bioactivity and Physical Properties,” was authored by MCP inventors Sunny Skaria and Kenneth J. Berk. It may be found at https://www.mdpi.com/2073-4360/13/13/2095.

Pulpdent pioneered the introduction of esthetic bioactive dental materials in 2013 with the introduction of ACTIVA BioACTIVE-RESTORATIVE, which will continue to be a leading restorative material for the company, the company said. MCP technology works in concert with the mechanism that drives ACTIVA BioACTIVE-RESTORATIVE and other ACTIVA products. The bioactive ACTIVA line currently includes ACTIVA BioACTIVE-CEMENT, ACTIVA BioACTIVE Base/Liner, ACTIVA Kids BioACTIVE-RESOTRATIVE, ACTIVA Presto, and ACTIVA Pronto.

Extensive independent research has validated the significance of bioactive restorative materials and their positive effect on patient outcomes, according to Pulpdent. The field of bioactive research in dentistry continues to expand as methods of observing bioactivity and measuring bioactive-assisted outcomes becomes more highly developed.

By definition, bioactive dental materials stimulate the natural remineralization process that helps protect teeth against caries. Bioactive restoratives also actively promote a bonded layer of apatite between the tooth and restoration. Pulpdent’s bioactive dental materials are acknowledged by the US Food and Drug Administration as meeting requirements to be termed “bioactive.”

More information on Crysta is available at https://pulpdent.com/crysta. More information on ACTIVA Presto is available at https://pulpdent.com/pulpdent-products/activa-presto.

(Source: Pulpdent)

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