PHILADELPHIA, US: It was previously believed that Streptococcus mutans was the main microorganism responsible for dental caries. However, in a recent study, researchers have discovered that another bacterial species, Selenomonas sputigena, plays a major role in dental caries development. The unique insights gained in the study could help in the development of new strategies for caries prevention.
In the study, the researchers analysed samples of plaque from the teeth of 300 children aged 3 to 5 years, half of whom had caries. They then validated their findings on a further set of 116 plaque samples from 3- to 5-year-olds. They found that, although S. sputigena does not cause caries on its own, S. sputigena interacts with S. mutans in a manner that enhances its cariogenic power.
“This was an unexpected finding that gives us new insights into the development of caries, highlights potential future targets for cavity prevention, and reveals novel mechanisms of bacterial biofilm formation that may be relevant in other clinical contexts,” said senior author Prof. Hyun Michel Koo, a founding director of the Center for Innovation and Precision Dentistry at the University of Pennsylvania School of Dental Medicine.
The researchers explained that S. mutans metabolises sugars to produce glucans to protect the biofilm bacteria and that S. sputigena can become trapped in the glucans. Once this occurs, S. sputigena grows rapidly, forming honeycomb-shaped superstructures that further encapsulate and protect S. mutans, thus increasing acid production within the plaque.
The study was a collaboration between the University of Pennsylvania School of Dental Medicine and the University of North Carolina at Chapel Hill Adams School of Dentistry and Gillings School of Global Public Health. “This was a perfect example of collaborative science that couldn’t have been done without the complementary expertise of many groups and individual investigators and trainees,” said co-author Prof. Kimon Divaris from the University of North Carolina at Chapel Hill.
The researchers are now planning to further investigate how S. sputigena ends up in the aerobic environment of the tooth surface. “This phenomenon in which a bacterium from one type of environment moves into a new environment and interacts with the bacteria living there, building these remarkable superstructures, should be of broad interest to microbiologists,” Prof. Koo concluded.
NEW YORK, NY, USA: NYU College of Dentistry researchers have identified a promising new approach for treating tooth hypersensitivity, while simultaneously ...
FORT MYERS, Fla., US: Although many college students recognise the impact that lifestyle choices have on oral health, minority students often have limited ...
CHICAGO, US: To improve the clinical decision-making of dentists, the American Dental Association (ADA) has recently released a new clinical practice ...
BOSTON, US: During the pandemic, the majority of dental professionals had to cease their dental activities in order to slow down the spread of COVID-19. The...
SAN FRANCISCO, Calif., USA: A team of Italian and Australian researches appears to have found physical proof that restorative dentistry dates to the Stone ...
NEW YORK, US: Oral tumours can cause agonising pain and thus greatly impair the quality of life of patients. Researchers from the New York University ...
LAKELAND, Fla., US: Although an increasing number of dentists and patients are choosing resin composites as restorative materials, amalgam is still widely ...
SAN DIMAS, Calif., US: In a fresh overview on a hot topic, researchers with Stevenson Dental Research Institute in California have released a curated guide ...
CHICAGO, Ill., USA: It’s safe for pregnant women to undergo dental treatment with local anesthetics, according to a new study published in the August ...
Education
Live webinar Tue. 6 August 2024 6:00 PM EST (New York)
Numerous studies have investigated prevalent personality types among dental students with a view to the predictive value for success in training. A new ...
Artificial intelligence (AI) in dentistry has started to bloom in recent years. From a dental perspective, applications of AI can be classified into ...
In this interview with Andreas Frank, Dental Tribune International explores the company’s advancements in dental technology. Frank discusses the impact of...
To post a reply please login or register