Dental News - Chip checks for oral cancer

Mike Williams, Rice News Staff

Mon. 9 August 2010

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The gentle touch of a brush on the tongue or cheek can help detect oral cancer with success rates comparable to more invasive techniques such as biopsies, according to preliminary studies by researchers at Rice University, the University of Texas Health Science Centers at Houston (UTHSC) and San Antonio and the University of Texas M.D. Anderson Cancer Center.

A new test that uses Rice’s diagnostic nano-bio-chip was found to be 97 per cent ‘sensitive’ and 93 per cent specific in detecting which patients had malignant or premalignant lesions, results that compared well with traditional tests.

The study is available online in the journal Cancer Prevention Research.

“One of the key discoveries in this paper is to show that the miniaturized, noninvasive approach produces about the same result as the pathologists do,” said John Mc-Devitt, the Brown-Wiess professor of chemistry and bioengineering at Rice.

His lab developed the novel nano-bio-chip technology at the university’s Bio-Science Research Collaborative.

Oral cancer afflicts more than 300,000 people a year, including 35,000 in the United States alone. The five-year survival rate is 60 per cent, but if oral cancer is detected early, that rate rises to 90 per cent.

McDevitt and his team are working to create an inexpensive chip that can differentiate premalignancies from the 95 per cent of lesions that will not become cancerous.

The minimally invasive technique would deliver results in 15 minutes instead of several days, as lab-based diagnostics do now. Instead of an invasive, painful biopsy, the new procedure requires just a light brush of the lesion on the cheek or tongue with an instrument that looks like a toothbrush.

“This area of diagnostics and testing has been terribly challenging for the scientific and clinical community,” said McDevitt, who came to Rice from the University of Texas at Austin in 2009. “Part of the problem is that there are no good tools currently available that work in a reliable way.”

He said patients with suspicious lesions, which are usually discovered by dentists or oral surgeons, end up getting scalpel or punch biopsies as often as every six months. “People trained in this area don’t have any trouble finding lesions,” McDevitt said.

“The issue is the next step — taking a chunk of someone’s cheek. The heart of this paper is developing a more humane and less painful way to do that diagnosis, and our technique has shown remarkable success in early trials.”

Nano-bio-chips are small, semiconductor-based devices that combine the ability to capture, stain and analyze biomarkers for a variety of health woes that also include cardiac disease, HIV and trauma injuries. Researchers hope the eventual deployment of nano-bio-chips will dramatically cut the cost of medical diagnostics and contribute significantly to the task of bringing quality health care to the world.

The new study compared results of traditional diagnostic tests to those obtained with nano-bio-chips on a small sample of 52 participants. All of the patients had visible oral lesions of leukoplakia or erythroplakia and had been referred to specialists for surgical biopsies or removal of the lesions.

The chips should also be able to see when an abnormality turns precancerous. “You want to catch it early on, as it’s transforming from pre-cancer to the earliest stages of cancer, and get it in stage one. Then the five-year survival rate is very high,” he said.

“Currently, most of the time, it’s captured in stage three, when the survivability is very low.”

The device is on the verge of entering a more extensive trial that will involve 500 patients in Houston, San Antonio and England. That could lead to an application for FDA approval in two to four years.

Eventually, McDevitt said, dentists may be the first line of defense against oral cancers, with the ability to catch early signs of the disease right there in the chair.

McDevitt’s co-authors include Rice senior research scientist Pierre Floriano, Rice postdoctoral associate Shannon Weigum and Spencer Redding, a professor and chair of the Department of Dental Diagnostic Science at theUTHSC at San Antonio.

Also contributing were: UTHSC San Antonio’s Chih-Ko Yeh, Stephen Westbrook and Alan Lin, all of the Department of Dental Diagnostic Science; H. Stan McGuff of the Department of Pathology; and Frank Miller, Fred Villarreal and Stephanie Rowan, all of the Department of Otolaryngology, Head and Neck Surgery; UTHSC Houston’s Nadarajah Vigneswaran of the Department of Diagnostic Science; and Michelle Williams of the Department of Pathology at the University of Texas M.D. Anderson Cancer Center.

The researchers received a Grand Opportunity Grant from the National Institute for Dental and Craniofacial Research Division of the National Institutes of Health for the work.

(Edited by Fred Michmershuizen, DTA)

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